SAFETY DATA SHEET. 1. Identification. Product identifier: DIMETHYLFORMAMIDE. Other means of identification. Product No.: , . View or download the N,N-Dimethylformamide MSDS (Material Safety Data Sheet) or SDS for from Merck. Print Date 05/08/ SECTION 1. PRODUCT AND COMPANY IDENTIFICATION. Product name.: N,N-Dimethylformamide. MSDS Number.
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The Royal Society of Chemistry.
DMF is miscible with water. You may be trying to access this site from a secured browser on the server.
It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production msfs pesticidesand in the manufacture of adhesivessynthetic leathersfibers, films, and surface coatings. Inorganic and organic based residual fluxes are highly soluble in DMF; therefore this solvent is used as a cleaner, for instance to dimethglformamide hot-dip tinned parts. Distillation is therefore conducted under reduced pressure at lower temperatures.
As for most amidesthe spectroscopic evidence indicates partial double bond character for the C-N and C-O bonds. Product Availability Check with local Sales Office to determine exact availability by country. The pharmaceutical industry uses DMF as a reaction and crystallization solvent because of its exceptional solvency parameters.
Jsds from ” https: Due to the high solubility of SO 2 in DMF, exhaust combustion streams from high sulfur containing fuels can be purified with CO 2 being recovered.
Another significant application is the use of DMF as a solvent for polyurethane-based coatings on dimethylfotmamide and artificial leather fabrics. London, ; pp 35— DMF is hydrolyzed by strong acids and bases, especially at elevated temperatures.
LC 50 median concentration. Lethal dose or concentration LDLC:. In Trost, Barry M. LD 50 median dose. Although currently impractical, DMF dimethylfotmamide be prepared from supercritical carbon dioxide using ruthenium -based catalysts. In the petrochemical industry DMF is used for the purification of acetylene from ethylene and butadiene from C4 streams. In one of its main uses in organic synthesisDMF is a reagent in the Vilsmeier—Haack reactionwhich is used to formylate aromatic compounds.
DMF is also used in epoxy based formulations. LC Lo lowest published. DMF is prepared by combining methyl formate dimethylformamkde dimethylamine dimthylformamide by reaction of dimethylamine with carbon monoxide. DMF is a common solvent for chemical reactions.
The acute LD50 oral, rats and mice is 2. This page was last edited on 12 Decemberat Please enable scripts and reload this page. DMF is also used as industrial paint stripper. DMF undergoes decarbonylation dimwthylformamide its boiling point to give dimethylamine. Spectral Database for Organic Compounds.
Eastman | Dimethylformamide (DMF)
Hepatotoxins Formamides Amide solvents. Commonly abbreviated as DMF although this initialism is sometimes used for dimethylfuranor dimethyl fumaratethis colourless liquid is miscible with water and the majority of organic liquids. Retrieved 27 June The solvent properties of DMF are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility.
HHHHH With sodium hydroxideDMF converts to formate and dimethylamine. On a pilot plant scale, on the other hand, several accidents have been reported.
DMF is widely used as a solvent, reagent and catalyst in the synthetic organic chemistry. It facilitates reactions that follow polar mechanisms, such as S N 2 reactions. The product is known as a universal solvent. Important Raw Materials and Intermediates. The primary use of DMF is as a solvent with low evaporation rate. Encyclopedia of Reagents for Organic Synthesis. Organolithium compounds react with DMF to give, dimfthylformamide hydrolysis, aldehydes.
DMF is used in the production of acrylic fibers and plastics.
As its name indicates, it is a derivative of formamidethe amide of formic acid.